South America is an extraordinary region to explore by cruise ship, offering everything from vibrant cities and historic ports to dramatic mountain ranges, remote wilderness and spectacular wildlife. From the colourful streets of Buenos Aires and the beautiful coastline of Uruguay to the rugged landscapes of Patagonia and the southernmost reaches of the continent, a South American cruise provides opportunities to discover some of the world’s most fascinating destinations.

Whether you are hoping to explore bustling cities, discover local culture, encounter incredible wildlife or admire breathtaking scenery, South America offers a remarkable variety of experiences. Depending on your itinerary, you might visit Argentina’s famous capital, explore the historic streets of Montevideo, discover the wildlife around Puerto Madryn or sail through the spectacular landscapes surrounding Cape Horn. Some itineraries also visit Ushuaia, often described as the city at the end of the world, which serves as an important gateway for cruises heading towards Antarctica.

Explore the South America cruise destination guides below for first hand experiences, practical information and inspiration to help you make the most of your time ashore. From independent sightseeing and wildlife excursions to scenic cruising through some of the continent’s most remote regions, these guides will help you discover what to expect and plan your own South American adventure.